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Article

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration.

The Journal of cell biology - 16 Apr 2012

Suraneni Praveen, Rubinstein Boris, Unruh Jay R, Durnin Michael, Hanein Dorit, Li Rong

Abstract excerpt

The Arp2/3 complex nucleates the formation of the dendritic actin network at the leading edge of motile cells, but it is still unclear if the Arp2/3 complex plays a critical role in lamellipodia protrusion and cell motility. Here, we differentiated motile fibroblast cells from isogenic mouse embryonic stem cells with or without disruption of the ARPC3 gene, which encodes the p21 subunit of the Arp2/3 complex....

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Source

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Identifiers

PMID: 22492726
DOI: 10.1083/jcb.201112113
PMCID: PMC3328382

Genes

ARPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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