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Article

Cell Migration: Integrating Signals from Front to Back

4 Dec 2003

Abstract excerpt

Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms...

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Identifiers

PMID: 14657486
DOI: 10.1126/science.1092053

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