Article

Long range mutual activation establishes Rho and Rac polarity during cell migration

2024-10-02

Abstract excerpt

In migrating cells, the GTPase Rac organizes a protrusive front, whereas Rho organizes a contractile back. How these GTPases are appropriately positioned at the opposite poles of migrating cells is unknown. Here we leverage optogenetics, manipulation of cell mechanics, and mathematical modeling to reveal a surprising mechanochemical long-range mutual activation of the front and back polarity programs that compleme...

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Literature Corpus work: cadef5e9-f735-5b9d-99ce-cdd21bce3e47
DOI: 10.1101/2024.10.01.616161

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