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Article

Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.

The Journal of cell biology - 6 Nov 2017

Böttcher Ralph T, Veelders Maik, Rombaut Pascaline, Faix Jan, Theodosiou Marina, Stradal Theresa E, Rottner Klemens, Zent Roy, Herzog Franz, Fässler Reinhard

Abstract excerpt

Cell spreading requires the coupling of actin-driven membrane protrusion and integrin-mediated adhesion to the extracellular matrix. The integrin-activating adaptor protein kindlin-2 plays a central role for cell adhesion and membrane protrusion by directly binding and recruiting paxillin to nascent adhesions. Here, we report that kindlin-2 has a dual role during initial cell spreading: it binds paxillin via the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28912124
DOI: 10.1083/jcb.201701176
PMCID: PMC5674885

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