Article

PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration

2024-09-15

Abstract excerpt

Symmetry breaking is a fundamental process that underlies key cellular behaviors such as cell polarity and migration, but the mechanism – how a uniform plasma membrane spontaneously transitions to an asymmetric state – is still unknown. Here in this study, using a combination of Dictyostelium amoeba, multiple mammalian leukocytes, and human cancer cells and 3D organoid systems, we monitored the localization dynam...

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Literature Corpus work: 2b242953-7793-57a4-8273-ab3f8fc68842
DOI: 10.1101/2024.09.15.613115

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