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Article

FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.

Nature cell biology - 1 Aug 2006

Ohta Yasutaka, Hartwig John H, Stossel Thomas P

Abstract excerpt

FilGAP is a newly recognized filamin A (FLNa)-binding RhoGTPase-activating protein. The GTPase-activating protein (GAP) activity of FilGAP is specific for Rac and FLNa binding targets FilGAP to sites of membrane protrusion, where it antagonizes Rac in vivo. Dominant-negative FilGAP constructs lacking GAP activity or knockdown of endogenous FilGAP by small interference RNA (siRNA) induce spontaneous lamellae...

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Identifiers

PMID: 16862148
DOI: 10.1038/ncb1437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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