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Article

Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning.

PloS one - 1 Jan 2011

Sero Julia E, Thodeti Charles K, Mammoto Akiko, Bakal Chris, Thomas Sheila, Ingber Donald E

Abstract excerpt

Physical interactions between cells and the extracellular matrix (ECM) guide directional migration by spatially controlling where cells form focal adhesions (FAs), which in turn regulate the extension of motile processes. Here we show that physical control of directional migration requires the FA scaffold protein paxillin. Using single-cell sized ECM islands to constrain cell shape, we found that fibroblasts...

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Identifiers

PMID: 22194823
DOI: 10.1371/journal.pone.0028303
PMCID: PMC3237434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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