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Article

Integrin-mediated signals regulated by members of the rho family of GTPases.

The Journal of cell biology - 27 Jul 1998

Clark E A, King W G, Brugge J S, Symons M, Hynes R O

Abstract excerpt

The organization of the actin cytoskeleton can be regulated by soluble factors that trigger signal transduction events involving the Rho family of GTPases. Since adhesive interactions are also capable of organizing the actin-based cytoskeleton, we examined the role of Cdc42-, Rac-, and Rho-dependent signaling pathways in regulating the cytoskeleton during integrin-mediated adhesion and cell spreading using...

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Identifiers

PMID: 9679153
DOI: 10.1083/jcb.142.2.573
PMCID: PMC2133065

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