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Article

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.

Current biology : CB - 22 Jun 2010

Serrels Bryan, Sandilands Emma, Serrels Alan, Baillie George, Houslay Miles D, Brunton Valerie G, Canel Marta, Machesky Laura M, Anderson Kurt I, Frame Margaret C

Abstract excerpt

A fundamental question in cell biology concerns how cells respond to their environment by polarizing after sensing directional cues. This requires the differential localization of protein complexes in cells, and it is important to identify and understand how these complexes function. Here we describe a novel "direction-sensing" pathway that links the integrin effector focal adhesion kinase (FAK), the molecular...

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Share to Cell Polarity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic Nucleotide Phosphodiesterases, Type 3

Share to Cyclic Nucleotide Phosphodiesterases, Type 4

Share to Focal Adhesion Protein-Tyrosine Kinases

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Source

Identifiers

PMID: 20493699
DOI: 10.1016/j.cub.2010.04.042

Genes

RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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