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Article

FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts.

Journal of cell science - 15 Mar 2008

Iwanicki Marcin P, Vomastek Tomas, Tilghman Robert W, Martin Karen H, Banerjee Jayashree, Wedegaertner Philip B, Parsons J Thomas

Abstract excerpt

A key step in cell migration is the dynamic formation and disassembly of adhesions at the front and the concomitant movement and release of adhesions in the rear of the cell. Fibroblasts maintained in the absence of serum have stable adhesions within the rear of the cell and exhibit reduced trailing-edge retraction resulting in an elongated cell phenotype. Addition of lysophosphatidic acid (LPA) induced the...

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Share to Cell Adhesion
Share to Focal Adhesion Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Lysophospholipids

Share to NIH 3T3 Cells

Share to rho-Associated Kinases

Share to Rho Guanine Nucleotide Exchange Factors

Share to rhoA GTP-Binding Protein

Source

Identifiers

PMID: 18303050
DOI: 10.1242/jcs.020941

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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