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Article

Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype.

Cell communication and signaling : CCS - 20 May 2016

Nunes de Miranda Susana M, Wilhelm Thomas, Huber Michael, Zorn Carolin N

Abstract excerpt

BACKGROUND: Antigen (Ag)/IgE-mediated mast cell (MC) responses play detrimental roles in allergic diseases. MC activation via the high-affinity receptor for IgE (FcεRI) is controlled by the Src family kinase Lyn. Lyn-deficient (-/-) bone marrow-derived MCs (BMMCs) have been shown by various laboratories to exert stronger activation of the PI3K pathway, degranulation, and production of pro-inflammatory cytokines...

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Source

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Identifiers

PMID: 27206658
DOI: 10.1186/s12964-016-0135-0
PMCID: PMC4874025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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