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Article

The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.

Blood - 1 Oct 2007

Hong Hong, Kitaura Jiro, Xiao Wenbin, Horejsi Vaclav, Ra Chisei, Lowell Clifford A, Kawakami Yuko, Kawakami Toshiaki

Abstract excerpt

IgE/antigen-dependent mast cell activation plays a central role in immediate hypersensitivity and other allergic reactions. The Src family tyrosine kinase (SFK) Lyn is activated by the cross-linking of high-affinity IgE receptors (FcepsilonRI). Activated Lyn phosphorylates the FcepsilonRI subunit...

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Identifiers

PMID: 17513616
DOI: 10.1182/blood-2007-01-066092
PMCID: PMC1988937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17513616-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.PMID 17513616Read ↗

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Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.Semantic proximity Read ↗

Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b.Semantic proximity Read ↗

A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.Semantic proximity Read ↗

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Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis.Semantic proximity Read ↗

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