Article
Role of acid sphingomyelinase in the regulation of mast cell function.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jan 2014
Yang W, Schmid E, Nurbaeva M K, Szteyn K, Leibrock C, Yan J, Schaller M, Gulbins E, Shumilina E, Lang F
Abstract excerpt
BACKGROUND: Degranulation of mast cells is stimulated by store-operated Ca(2+) -entry (SOCE). In other cell types, Ca(2+) -entry is modified by ceramide. Exogenously added ceramide has been shown to trigger mast cell apoptosis. Effects of endogenously produced ceramide in mast cells remained, however, elusive. Ceramide may be produced from sphingomyelin by acid sphingomyelinase (Asm). OBJECTIVE: This study...
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