Article

SR-BI regulates the synergistic mast cell response by modulating the plasma membrane-associated cholesterol pool

2023-06-24

Abstract excerpt

The high-affinity IgE receptor FcεRI is the fundamental mast cell (MC) receptor responsible for the involvement of MCs in IgE-associated allergic disorders. Activation of the FcεRI is achieved via crosslinking by multivalent antigen (Ag) recognized by IgE, which results in degranulation and pro-inflammatory cytokine production. In comparison to the T and B cell receptor complexes, for which several co-receptors th...

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Literature Corpus work: e6dd8ffd-125b-588b-8217-5dbb7277eb4d
DOI: 10.1101/2023.06.21.545859

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