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Article

Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2011

Maxwell Mhairi J, Duan Mubing, Armes Jane E, Anderson Gary P, Tarlinton David M, Hibbs Margaret L

Abstract excerpt

Alternatively activated M2 macrophages are implicated as both regulators and agents of lung disease, but their control is poorly understood. SHIP-1 is a 5' inositol phosphatase that negatively regulates the PI3K signaling pathway implicated in inflammation. SHIP-1-deficient mice have defects in hematopoiesis and B cell development, and die prematurely due to consolidation of lungs with M2-skewed macrophages....

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Identifiers

PMID: 21572033
DOI: 10.4049/jimmunol.1004185

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