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Article

Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2000

Kawakami Y, Kitaura J, Satterthwaite A B, Kato R M, Asai K, Hartman S E, Maeda-Yamamoto M, Lowell C A, Rawlings D J, Witte O N, Kawakami T

Abstract excerpt

Protein-tyrosine kinases play crucial roles in mast cell activation through the high-affinity IgE receptor (FcepsilonRI). In this study, we have made the following observations on growth properties and FcepsilonRI-mediated signal transduction of primary cultured mast cells from Btk-, Lyn-, and Btk/Lyn-deficient mice. First, Lyn deficiency partially reversed the survival effect of Btk deficiency. Second,...

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Source

Identifiers

PMID: 10903718
DOI: 10.4049/jimmunol.165.3.1210

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.PMID 10903718Read ↗

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