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Article

SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2002

Kalesnikoff Janet, Baur Nicole, Leitges Michael, Hughes Michael R, Damen Jacqueline E, Huber Michael, Krystal Gerald

Abstract excerpt

We demonstrate in this study that IgE + Ag-induced proinflammatory cytokine production is substantially higher in Src homology-2-containing inositol 5'-phosphatase (SHIP)(-/-) than in SHIP(+/+) bone marrow-derived mast cells (BMMCs). Focusing on IL-6, we found that the repression of IL-6 mRNA and...

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Source

Identifiers

PMID: 11971024
DOI: 10.4049/jimmunol.168.9.4737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11971024-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity.PMID 11971024Read ↗

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