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Article

The role of SHIP in macrophages.

Frontiers in bioscience : a journal and virtual library - 1 May 2007

Sly Laura M, Ho Victor, Antignano Frann, Ruschmann Jens, Hamilton Melisa, Lam Vivian, Rauh Michael J, Krystal Gerald

Abstract excerpt

The SH2-containing inositol-5'-phosphatase, SHIP, represses the proliferation, survival, and activation of hematopoietic cells, in large part by translocating to membranes following extracellular stimulation and hydrolysing the phosphatidylinositol-3-kinase (PI3K)-generated second messenger PI-3,...

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Identifiers

PMID: 17485263
DOI: 10.2741/2276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17485263-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The role of SHIP in macrophages.PMID 17485263Read ↗

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SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC-derived modelSemantic proximity Read ↗

BCR/ABL Directly Inhibits Expression of SHIP, an SH2-Containing Polyinositol-5-Phosphatase Involved in the Regulation of HematopoiesisSemantic proximity Read ↗

Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype.Semantic proximity Read ↗

Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses.Semantic proximity Read ↗

Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow TransplantationSemantic proximity Read ↗

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Myeloid Specific Ablation of SHIP1 Boosts ex vivo Expansion and Regulatory Function of Myeloid-Derived Suppressor Cells in Inflammatory ArthritisSemantic proximity Read ↗

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