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Article

The role of SHIP in macrophages.

Frontiers in bioscience : a journal and virtual library - 1 May 2007

Sly Laura M, Ho Victor, Antignano Frann, Ruschmann Jens, Hamilton Melisa, Lam Vivian, Rauh Michael J, Krystal Gerald

Abstract excerpt

The SH2-containing inositol-5'-phosphatase, SHIP, represses the proliferation, survival, and activation of hematopoietic cells, in large part by translocating to membranes following extracellular stimulation and hydrolysing the phosphatidylinositol-3-kinase (PI3K)-generated second messenger PI-3,4,5-P3 (PIP3) to PI-3,4-P2. SHIP-/- mice have, as a result, an increased number of monocyte/macrophages because their...

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PMID: 17485263
DOI: 10.2741/2276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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