Article
Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity.
The Journal of experimental medicine - 16 Dec 2002
Hibbs Margaret L, Harder Kenneth W, Armes Jane, Kountouri Nicole, Quilici Cathy, Casagranda Franca, Dunn Ashley R, Tarlinton David M
Abstract excerpt
Genetic ablation of the Lyn tyrosine kinase has revealed unique inhibitory roles in B lymphocyte signaling. We now report the consequences of sustained activation of Lyn in vivo using a targeted gain-of-function mutation (Lyn(up/up) mice). Lyn(up/up) mice have reduced numbers of conventional B lymphocytes, down-regulated surface immunoglobulin M and costimulatory molecules, and elevated numbers of B1a B cells....
Topics
- Animals
- Antigen-Antibody Complex
- Antigens, CD
- Autoantibodies
- Autoimmune Diseases
- Autoimmunity
- B-Lymphocytes
- Calcium
- Cell Separation
- Cells, Cultured
- Enzyme Activation