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Article

Requirement for CD45 in fine-tuning mast cell responses mediated by different ligand-receptor systems.

Cellular signalling - 1 Aug 2009

Grochowy Gordon, Hermiston Michelle L, Kuhny Marcel, Weiss Arthur, Huber Michael

Abstract excerpt

The receptor-like protein tyrosine phosphatase CD45, the most abundant cell surface phosphatase on all nucleated hemopoietic cells, is a critical regulator of the activation status of Src family kinases (SFKs). To study the impact of CD45 on mast cell function, we compare bone marrow-derived mast cells (BMMCs) from CD45-deficient mice and from mice expressing an activating point mutation (E613R) in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19332117
DOI: 10.1016/j.cellsig.2009.03.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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