Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts in Goeckerman therapy.

doi:10.1016/j.toxlet.2016.05.009

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Article

Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts in Goeckerman therapy.

Toxicology letters - 25 Jul 2016

Beranek Martin, Fiala Zdenek, Kremlacek Jan, Andrys Ctirad, Hamakova Kvetoslava, Chmelarova Marcela, Palicka Vladimir, Borska Lenka

Abstract excerpt

Goeckerman therapy (GT) for psoriasis combines the therapeutic effect of crude coal tar (CCT) and ultraviolet radiation (UVR). CCT contains polycyclic aromatic hydrocarbons, some of which can form DNA adducts that may induce mutations and contribute to carcinogenesis. The aim of our work was to evaluate the relationship between concentrations of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts (BPDE-DNA adducts)...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Administration, Cutaneous
Adult
Aged
Aged, 80 and over
Benzo(a)pyrene
Biotransformation
Coal Tar
Cytochrome P-450 CYP1B1
DNA Adducts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Damage

Epoxide Hydrolases

Female

Gene Frequency

Glucuronosyltransferase

Glutathione Transferase

Heterozygote

Homozygote

Source

Open in PubMed

Identifiers

PMID: 27188524
DOI: 10.1016/j.toxlet.2016.05.009

Genes

EPHX1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27188524-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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