Article
ERCC1 and ERCC2 haplotype modulates induced BPDE-DNA adducts in primary cultured lymphocytes.
PloS one - 1 Jan 2013
Lu Xiaobo, Liu Yanhua, Yu Tao, Xiao Sha, Bao Xiaoyan, Pan Liang, Zhu Guolian, Cai Yuan, Liu Qiufang, Jin Cuihong, Yang Jinghua, Wu Shengwen, An Li, van der Straaten Tahar
Abstract excerpt
BACKGROUND: Benzo[a]pyrene(B[a]P), and its ultimate metabolite Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), are classic DNA damaging carcinogens. DNA damage caused by BPDE is normally repaired by Nucleotide Excision Repair (NER), of which ERCC1 and ERCC2/XPD exert an indispensable role. Genetic variations in ERCC1 and ERCC2 have been related to DNA repair efficiency. In this study we used lymphocytes from healthy...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Alleles
- Benzo(a)pyrene
- Carcinogens
- Cells, Cultured
- DNA Adducts