Article
Droplet Digital PCR Analysis of GSTM1 Deletion Polymorphism in Psoriatic Subjects Treated with Goeckerman Therapy.
Acta medica (Hradec Kralove) - 1 Jan 2000
Beránek Martin, Fiala Zdeněk, Kremláček Jan, Andrýs Ctirad, Hamáková Květoslava, Palička Vladimír, Borská Lenka
Abstract excerpt
Goeckerman therapy (GT) represents an effective treatment of psoriasis including a combination of pharmaceutical grade crude coal tar (CCT) and ultraviolet irradiation (UV-R). Coal tar contains a mixture of polycyclic aromatic hydrocarbons. The best known carcinogenic polyaromate - benzo[a]pyrene is metabolized into a highly reactive benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE). Glutathione S-transferase M1...
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