Genetic polymorphisms in 19q13.3 genes associated with alteration of repair capacity to BPDE-DNA adducts in primary cultured lymphocytes.

doi:10.1016/j.mrgentox.2016.10.004

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Article

Genetic polymorphisms in 19q13.3 genes associated with alteration of repair capacity to BPDE-DNA adducts in primary cultured lymphocytes.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Dec 2016

Xiao Mingyang, Xiao Sha, Straaten Tahar van der, Xue Ping, Zhang Guopei, Zheng Xiao, Zhang Qianye, Cai Yuan, Jin Cuihong, Yang Jinghua, Wu Shengwen, Zhu Guolian, Lu Xiaobo

Abstract excerpt

Benzo[a]pyrene(B[a]P), and its ultimate metabolite Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), are classic DNA damaging carcinogens. DNA damage in cells caused by BPDE is normally repaired by Nucleotide Excision Repair (NER) and Base Excision Repair (BER). Genetic variations in NER and BER can change individual DNA repair capacity to DNA damage induced by BPDE. In the present study we determined the number of in...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Adult
Aged
Alleles
Benzo(a)pyrene
Carcinogens, Environmental
Cells, Cultured
Chromosomes, Human, Pair 19
Comet Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA

DNA Adducts

DNA Damage

DNA Repair

Female

Genotype

Humans

Lymphocytes

Male

Source

Open in PubMed

Identifiers

PMID: 27908386
DOI: 10.1016/j.mrgentox.2016.10.004

Genes

CAST
XRCC1
XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27908386-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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