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Article

Psoriatic skin transcript phenotype: androgen/estrogen and cortisone/cortisol imbalance with increasing DNA damage response.

Molecular biology reports - 24 Aug 2024

Başar Kılıç Şeyma, Taheri Serpil, Mehmetbeyoğlu Duman Ecmel, Öksüm Solak Eda, Yılmaz Şükranlı Zeynep, Rassoulzadegan Minoo, Borlu Murat

Abstract excerpt

BACKGROUND: Patients prone to psoriasis suffer after a breakdown of the epidermal barrier and develop poorly healing lesions with abnormal proliferation of keratinocytes. Strong inflammatory reactions with genotoxicity (short telomeres) suggest impaired immune defenses with DNA damage repair response (DDR) in patients with psoriasis. Recent evidence indicates the existence of crosstalk mechanisms linking the DDR...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Androgen

Source

Identifiers

PMID: 39180588
DOI: 10.1007/s11033-024-09782-1

Genes

AR
ESR1
ESR2
HSD11B1
NR3C1
NR3C2
POLH
RAD1
SMC1A
SSBP3
TREX1
EXO1
HSD11B2
HUS1
RAD18
TREX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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