Article
Glutathione-S-transferase T1 genotyping and phenotyping in psoriasis patients receiving treatment with oral fumaric acid esters.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 May 2014
Gambichler T, Kreuter A, Susok L, Skrygan M, Rotterdam S, Höxtermann S, Müller M, Tigges C, Altmeyer P, Lahner N
Abstract excerpt
BACKGROUND: Glutathione S-transferases (GSTs) are involved in detoxification of xenobiotics such as fumaric acid esters (FAE). OBJECTIVES: To perform GSTT1 geno- and phenotyping in psoriasis patients treated with FAE to find out whether the responder status and/or occurrence of side-effects are associated with allelic variants and enzymatic activity of GSTT1. METHODS: We treated 106 psoriasis patients with FAE....
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