Article
Excision repair of BPDE-adducts in human lymphocytes: diminished capacity associated with ERCC1 C8092A (rs3212986) polymorphism.
Archives of toxicology - 1 Apr 2013
Yu Tao, Liu Yanhua, Lu Xiaobo, Xiao Sha, Cai Yuan, Jin Cuihong, Liu Qiufang, Yang Jinghua, Wu Shengwen, Bao Xiaoyan, Pan Liang, van der Straaten Tahar
Abstract excerpt
Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), a metabolite of Benzo[a]pyrene (B[a]P), is a high-risk factor for development of a number of cancers. DNA damage caused by BPDE is normally repaired by Nucleotide Excision Repair system of which ERCC1 exerts an important role. We investigated whether two single nucleotide polymorphisms in ERCC1 (C19007T; rs11615 and C8092A; rs3213986) affected the repair...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Adolescent
- Adult
- Aged
- Aged, 80 and over