Article

Markers of psoriatic skin phenotype: androgen/estrogen and cortisone/cortisol imbalance, and DNA damage

2022-10-31

Abstract excerpt

<h4>ABSTRACT</h4> Patients prone to psoriasis suffer after a breakdown of the epidermal barrier and develop poorly healing lesions with abnormal proliferation of keratinocytes. Strong inflammatory reactions with genotoxicity (short telomeres) suggest impaired immune defences with DNA damage repair response (DDR) in patients with psoriasis. Recent evidence indicates the existence of crosstalk mechanisms linking the...

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Literature Corpus work: 7d672ad1-a409-5393-a285-a7351cfc90dd
DOI: 10.1101/2022.10.25.22281520

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