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Article

A simple yet accurate correction for winner's curse can predict signals discovered in much larger genome scans.

Bioinformatics (Oxford, England) - 1 Sept 2016

Bigdeli T Bernard, Lee Donghyung, Webb Bradley Todd, Riley Brien P, Vladimirov Vladimir I, Fanous Ayman H, Kendler Kenneth S, Bacanu Silviu-Alin

Abstract excerpt

MOTIVATION: For genetic studies, statistically significant variants explain far less trait variance than 'sub-threshold' association signals. To dimension follow-up studies, researchers need to accurately estimate 'true' effect sizes at each SNP, e.g. the true mean of odds ratios (ORs)/regression coefficients (RRs) or Z-score noncentralities. Naïve estimates of effect sizes incur winner's curse biases, which are...

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PMID: 27187203
DOI: 10.1093/bioinformatics/btw303
PMCID: PMC5013908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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