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Article

Review and further developments in statistical corrections for Winner's Curse in genetic association studies.

PLoS genetics - 1 Sept 2023

Forde Amanda, Hemani Gibran, Ferguson John

Abstract excerpt

Genome-wide association studies (GWAS) are commonly used to identify genomic variants that are associated with complex traits, and estimate the magnitude of this association for each variant. However, it has been widely observed that the association estimates of variants tend to be lower in a replication study than in the study that discovered those associations. A phenomenon known as Winner's Curse is...

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PMID: 37721937
DOI: 10.1371/journal.pgen.1010546
PMCID: PMC10538662

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