Article

mBAT-combo: a more powerful test to detect gene-trait associations from GWAS data

2022-06-29

Abstract excerpt

Gene-based association tests aggregate multiple SNP-trait associations into sets defined by gene boundaries. Since genes have a direct biological link to downstream function, gene-based test results are widely used in post-GWAS analysis. A common approach for gene-based tests is to combine SNPs associations by computing the sum of χ 2 statistics. However, this strategy ignores the directions of SNP effects, which...

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Literature Corpus work: 4e0eb8a5-e4ee-57c0-bc36-aa347a20f797
DOI: 10.1101/2022.06.27.497850

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