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Article

Metasubtract: an R-package to analytically produce leave-one-out meta-analysis GWAS summary statistics.

Bioinformatics (Oxford, England) - 15 Aug 2020

Nolte Ilja M

Abstract excerpt

SUMMARY: statistics from a meta-analysis of genome-wide association studies (meta-GWAS) can be used for many follow-up analyses. One valuable application is the creation of polygenic scores. However, if polygenic scores are calculated in a validation cohort that was part of the meta-GWAS consortium, this cohort is not independent and analyses will therefore yield inflated results. The R package 'MetaSubtract' was...

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Identifiers

PMID: 32696040
DOI: 10.1093/bioinformatics/btaa570
PMCID: PMC7750933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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