Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantifying and correcting for the winner's curse in genetic association studies.

Genetic epidemiology - 1 Jul 2009

Xiao Rui, Boehnke Michael

Abstract excerpt

Genetic association studies are a powerful tool to detect genetic variants that predispose to human disease. Once an associated variant is identified, investigators are also interested in estimating the effect of the identified variant on disease risk. Estimates of the genetic effect based on new association findings tend to be upwardly biased due to a phenomenon known as the "winner's curse." Overestimation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Genome, Human
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Likelihood Functions

Share to Models, Statistical

Share to Models, Theoretical

Share to Odds Ratio

Share to Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 19140131
DOI: 10.1002/gepi.20398
PMCID: PMC2706290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantifying and correcting for the winner's curse in genetic association studies.PMID 19140131Read ↗

Review and further developments in statistical corrections for Winner's Curse in genetic association studies.Semantic proximity Read ↗

Curses--winner's and otherwise--in genetic epidemiology.Semantic proximity Read ↗

Bias-reduced estimators and confidence intervals for odds ratios in genome-wide association studies.Semantic proximity Read ↗

Quantifying and correcting for the winner's curse in quantitative-trait association studies.Semantic proximity Read ↗

Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.Semantic proximity Read ↗

Empirical Bayes correction for the Winner's Curse in genetic association studies.Semantic proximity Read ↗

Upward bias in odds ratio estimates from genome-wide association studies.Semantic proximity Read ↗

Accurate modeling of replication rates in genome-wide association studies by accounting for Winner’s Curse and study-specific heterogeneitySemantic proximity Read ↗

Accurate modeling of replication rates in genome-wide association studies by accounting for Winner's Curse and study-specific heterogeneity.Semantic proximity Read ↗

A general framework for two-stage analysis of genome-wide association studies and its application to case-control studies.Semantic proximity Read ↗

Correcting away the hidden heritability.Semantic proximity Read ↗

Correcting estimators of theta and Tajima's D for ascertainment biases caused by the single-nucleotide polymorphism discovery process.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.