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Article

mBAT-combo: A more powerful test to detect gene-trait associations from GWAS data.

American journal of human genetics - 5 Jan 2023

Li Ang, Liu Shouye, Bakshi Andrew, Jiang Longda, Chen Wenhan, Zheng Zhili, Sullivan Patrick F, Visscher Peter M, Wray Naomi R, Yang Jian, Zeng Jian

Abstract excerpt

Gene-based association tests aggregate multiple SNP-trait associations into sets defined by gene boundaries and are widely used in post-GWAS analysis. A common approach for gene-based tests is to combine SNPs associations by computing the sum of χ2 statistics. However, this strategy ignores the directions of SNP effects, which could result in a loss of power for SNPs with masking effects, e.g., when the product...

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PMID: 36608683
DOI: 10.1016/j.ajhg.2022.12.006
PMCID: PMC9892780

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