Article

Accurate modeling of replication rates in genome-wide association studies by accounting for Winner’s Curse and study-specific heterogeneity

2019-11-30

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex human traits, but only a fraction of variants identified in discovery studies achieve significance in replication studies. Replication in GWAS has been well-studied in the context of Winner’s Curse, which is the inflation of effect size estimates for significant variants due to statistical chance. However,...

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Literature Corpus work: b47459dc-b887-5c5b-bf78-32c2b986ce2a
DOI: 10.1101/856898

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