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Article

Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study.

Genetic epidemiology - 1 Sept 2011

So Hon-Cheong, Li Miaoxin, Sham Pak C

Abstract excerpt

Genome-wide association studies (GWAS) have become increasingly popular recently and contributed to the discovery of many susceptibility variants. However, a large proportion of the heritability still remained unexplained. This observation raises queries regarding the ability of GWAS to uncover the genetic basis of complex diseases. In this study, we propose a simple and fast statistical framework to estimate the...

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PMID: 21618601
DOI: 10.1002/gepi.20593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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