Article
Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.
Frontiers in immunology - 1 Jan 2020
Motwani Keshav, Peters Leeana D, Vliegen Willem H, El-Sayed Ahmed Gomaa, Seay Howard R, Lopez M Cecilia, Baker Henry V, Posgai Amanda L, Brusko Maigan A, Perry Daniel J, Bacher Rhonda, Larkin Joseph, Haller Michael J, Brusko Todd M
Abstract excerpt
The human T lymphocyte compartment is highly dynamic over the course of a lifetime. Of the many changes, perhaps most notable is the transition from a predominantly naïve T cell state at birth to the acquisition of antigen-experienced memory and effector subsets following environmental exposures. These phenotypic changes, including the induction of T cell exhaustion and senescence, have the potential to...
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