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Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells

1 Jan 2021

Abstract excerpt

Whereas the human fetal immune system is poised to generate immune tolerance and suppress inflammation in utero, an adult-like immune system emerges to orchestrate anti-pathogen immune responses in post-natal life. It has been posited that cells of the adult immune system arise as a discrete ontological "layer" of hematopoietic stem-progenitor cells (HSPCs) and their progeny; evidence supporting this model in...

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Immune responses and vaccinations
Neonatal Respiratory Health Research
Reproductive System and Pregnancy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33406429
DOI: 10.1016/j.celrep.2020.108573

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