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Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates

19 Dec 2017

Abstract excerpt

Respiratory support improvements have aided survival of premature neonates, but infection susceptibility remains a predominant problem. We previously reported that neonatal mice have a rapidly-evolving T-cell receptor (TCR) repertoire that impairs CD8+ T cell immunity. To understand the impact of prematurity on the human CD8+ TCR repertoire, we performed next generation sequencing (NGS) of the...

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Share to Infant Nutrition and Health
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PMID: 29312340
DOI: 10.3389/fimmu.2017.01859

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