Article

Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires

2016-02-09

Abstract excerpt

The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a “public” repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is downregulat...

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Literature Corpus work: eb35bec5-a92b-5e64-a54f-8208a9fa83ef
DOI: 10.1101/039297

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