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Article

Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires.

PLoS computational biology - 1 Jul 2017

Pogorelyy Mikhail V, Elhanati Yuval, Marcou Quentin, Sycheva Anastasiia L, Komech Ekaterina A, Nazarov Vadim I, Britanova Olga V, Chudakov Dmitriy M, Mamedov Ilgar Z, Lebedev Yury B, Mora Thierry, Walczak Aleksandra M

Abstract excerpt

The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Gene Rearrangement, T-Lymphocyte

Share to Receptors, Antigen, T-Cell

Share to Recombination, Genetic

Share to T-Cell Antigen Receptor Specificity

Share to Twins, Monozygotic

Source

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Identifiers

PMID: 28683116
DOI: 10.1371/journal.pcbi.1005572
PMCID: PMC5500008

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