Article
Clonal genotype and population structure inference from single-cell tumor sequencing.
Nature methods - 1 Jul 2016
Roth Andrew, McPherson Andrew, Laks Emma, Biele Justina, Yap Damian, Wan Adrian, Smith Maia A, Nielsen Cydney B, McAlpine Jessica N, Aparicio Samuel, Bouchard-Côté Alexandre, Shah Sohrab P
Abstract excerpt
Single-cell DNA sequencing has great potential to reveal the clonal genotypes and population structure of human cancers. However, single-cell data suffer from missing values and biased allelic counts as well as false genotype measurements owing to the sequencing of multiple cells. We describe the Single Cell Genotyper (https://bitbucket.org/aroth85/scg), an open-source software based on a statistical model...
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