Article

SiCloneFit: Bayesian inference of population structure, genotype,and phylogeny of tumor clones from single-cell genome sequencing data

2018-08-17

Abstract excerpt

Accumulation and selection of somatic mutations in a Darwinian framework result in intra-tumor heterogeneity (ITH) that poses significant challenges to the diagnosis and clinical therapy of cancer. Identification of the tumor cell populations (clones) and reconstruction of their evolutionary relationship can elucidate this heterogeneity. Recently developed single-cell DNA sequencing (SCS) technologies promise to r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f184ea4-00e8-5f7d-a06e-efed2ec7a608
DOI: 10.1101/394262

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SiCloneFit: Bayesian inference of population structure, genotype,and phylogeny of tumor clones from single-cell genome sequencing dataDOI 10.1101/394262Read

<i>BiTSC</i> 2: Bayesian inference of tumor clonal tree by joint analysis of single-cell SNV and CNA dataSemantic proximity Read

PhyClone: Accurate Bayesian reconstruction of cancer phylogenies from bulk sequencingSemantic proximity Read

Clonal genotype and population structure inference from single-cell tumor sequencing.Semantic proximity Read

PhyClone: accurate Bayesian reconstruction of cancer phylogenies from bulk sequencing.Semantic proximity Read

SC-BIG: A Hierarchical Bayesian Model for Bulk-Informed Single Nucleotide Variant Calling in Single CellsSemantic proximity Read

PyClone: statistical inference of clonal population structure in cancer.Semantic proximity Read

Computational enhancement of single-cell sequences for inferring tumor evolutionSemantic proximity Read

Bayesian inference for copy number intra-tumoral heterogeneity from single-cell RNA-sequencing dataSemantic proximity Read

Computational enhancement of single-cell sequences for inferring tumor evolutionSemantic proximity Read

Single-cell mutation identification via phylogenetic inferenceSemantic proximity Read

Power and pitfalls of computational methods for inferring clone phylogenies and mutation orders from bulk sequencing dataSemantic proximity Read

A Combinatorial Approach for Single-cell Variant Detection via Phylogenetic InferenceSemantic proximity Read