Article

Ccube: A fast and robust method for estimating cancer cell fractions

2018-12-02

Abstract excerpt

Estimating and clustering cancer cell fractions of genomic alterations are central tasks for studying intratumour heterogeneity. We present Ccube, a probabilistic framework for inferring the cancer cell fraction of somatic point mutations and the subclonal composition from whole-genome sequencing data. We develop a variational inference method for model fitting, which allows us to handle samples with large number...

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Literature Corpus work: f83949be-6c89-590c-b588-012e3aaa53a0
DOI: 10.1101/484402

Open publication

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