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Article

CellPhy: accurate and fast probabilistic inference of single-cell phylogenies from scDNA-seq data.

Genome biology - 26 Jan 2022

Kozlov Alexey, Alves Joao M, Stamatakis Alexandros, Posada David

Abstract excerpt

We introduce CellPhy, a maximum likelihood framework for inferring phylogenetic trees from somatic single-cell single-nucleotide variants. CellPhy leverages a finite-site Markov genotype model with 16 diploid states and considers amplification error and allelic dropout. We implement CellPhy into RAxML-NG, a widely used phylogenetic inference package that provides statistical confidence measurements and scales...

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Identifiers

PMID: 35081992
DOI: 10.1186/s13059-021-02583-w
PMCID: PMC8790911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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