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CellCoal: Coalescent Simulation of Single-Cell Sequencing Samples.

Molecular biology and evolution - 1 May 2020

Posada David

Abstract excerpt

Our capacity to study individual cells has enabled a new level of resolution for understanding complex biological systems such as multicellular organisms or microbial communities. Not surprisingly, several methods have been developed in recent years with a formidable potential to investigate the somatic evolution of single cells in both healthy and pathological tissues. However, single-cell sequencing data can be...

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PMID: 32027371
DOI: 10.1093/molbev/msaa025
PMCID: PMC7182211

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