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Article

The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas.

Oncotarget - 28 Jun 2016

Lim Chul-Hyun, Cho Yu Kyung, Kim Sang Woo, Choi Myung-Gyu, Rhee Je-Keun, Chung Yeun-Jun, Lee Sug-Hyung, Kim Tae-Min

Abstract excerpt

Mutation profiles and intratumoral heterogeneity are not well understood for benign gastric adenomas, some of which progress into malignant gastric adenocarcinomas. In this study, we performed whole-exome sequencing of three microsatellite stable (MSS) and two microsatellite instability-high (MSI-H) gastric adenomas with three regional tumor biopsies per case. We observed that the mutation abundance of benign...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27175599
DOI: 10.18632/oncotarget.9250
PMCID: PMC5129968

Genes

APC
ARID2
ERBB2
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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