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Article

Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine.

Genome medicine - 8 Nov 2021

Röcken Christoph, Amallraja Anu, Halske Christine, Opasic Luka, Traulsen Arne, Behrens Hans-Michael, Krüger Sandra, Liu Anne, Haag Jochen, Egberts Jan-Hendrik, Rosenstiel Philip, Meißner Tobias

Abstract excerpt

BACKGROUND: Cancer is a somatic evolutionary disease and adenocarcinomas of the stomach and gastroesophageal junction (GC) may serve as a two-dimensional model of cancer expansion, in which tumor subclones are not evenly mixed during tumor progression but rather spatially separated and diversified. We hypothesize that precision medicine efforts are compromised when clinical decisions are based on a single-sample...

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Identifiers

PMID: 34749812
DOI: 10.1186/s13073-021-00975-y
PMCID: PMC8576943

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