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Article

Whole-genome reconstruction and mutational signatures in gastric cancer.

Genome biology - 13 Dec 2012

Nagarajan Niranjan, Bertrand Denis, Hillmer Axel M, Zang Zhi Jiang, Yao Fei, Jacques Pierre-Étienne, Teo Audrey S M, Cutcutache Ioana, Zhang Zhenshui, Lee Wah Heng, Sia Yee Yen, Gao Song, Ariyaratne Pramila N, Ho Andrea, Woo Xing Yi, Veeravali Lavanya, Ong Choon Kiat, Deng Niantao, Desai Kartiki V, Khor Chiea Chuen, Hibberd Martin L, Shahab Atif, Rao Jaideepraj, Wu Mengchu, Teh Ming, Zhu Feng, Chin Sze Yung, Pang Brendan, So Jimmy B Y, Bourque Guillaume, Soong Richie, Sung Wing-Kin, Tean Teh Bin, Rozen Steven, Ruan Xiaoan, Yeoh Khay Guan, Tan Patrick B O, Ruan Yijun

Abstract excerpt

BACKGROUND: Gastric cancer is the second highest cause of global cancer mortality. To explore the complete repertoire of somatic alterations in gastric cancer, we combined massively parallel short read and DNA paired-end tag sequencing to present the first whole-genome analysis of two gastric adenocarcinomas, one with chromosomal instability and the other with microsatellite instability. RESULTS: Integrative...

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Identifiers

PMID: 23237666
DOI: 10.1186/gb-2012-13-12-r115
PMCID: PMC4056366

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KRAS
LMAN1
PAPPA
RPL22

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