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Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression

2023-04-11

Abstract excerpt

Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. We analyzed 1256 gastric samples (1152 IMs) from 692 subjects through a prospective 10-year study. We identified 26 IM driver genes in diverse pathways including chromatin regulation ( ARID1A ) and intestinal homeostasis ( SOX9 ), largely occurring as small clonal events. Analysis of...

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Literature Corpus work
fcc4d431-661c-578c-adfd-5f2871cd07b2
DOI
10.1101/2023.04.10.536195
Open publication

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Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer ProgressionDOI 10.1101/2023.04.10.536195
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